Feasibility of detecting atrophy relevant for disability and cognition in multiple sclerosis using 3D-FLAIR.

ABSTRACT:

Background and objectives

Disability and cognitive impairment are known to be related to brain atrophy in multiple sclerosis (MS), but 3D-T1 imaging required for brain volumetrics is often unavailable in clinical protocols, unlike 3D-FLAIR. Here our aim was to investigate whether brain volumes derived from 3D-FLAIR images result in similar associations with disability and cognition in MS as do those derived from 3D-T1 images.

Methods

3T-MRI scans of 329 MS patients and 76 healthy controls were included in this cross-sectional study. Brain volumes were derived using FreeSurfer on 3D-T1 and compared with brain volumes derived with SynthSeg and SAMSEG on 3D-FLAIR. Relative agreement was evaluated by calculating the intraclass correlation coefficient (ICC) of the 3D-T1 and 3D-FL

SUBMITTER: Noteboom S 

PROVIDER: S-EPMC10576669 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature