Deciphering the immune reaction leading to spontaneous melanoma regression: initial role of MHCII⁺ CD163^- macrophages.

ABSTRACT: The human cutaneous metastatic melanoma is the deadliest skin cancer. Partial, or less frequently complete spontaneous regressions could be observed, mainly mediated by T cells. Nevertheless, the underlying mechanisms are not fully unraveled. We investigated the first events of the immune response related to cancer regression in Melanoma-bearing Libechov Minipigs (MeLiM), a unique swine model of cutaneous melanoma that regresses spontaneously. Using a multiparameter flow cytometry strategy and integrating new clinical and histological criteria of the regression, we show that T cells and B cells are present only in the late stages, arguing against their role in the initial destruction of malignant cells. NK cells infiltrate the tumors before T cells and therefore might be involved in the in

SUBMITTER: Blanc F 

PROVIDER: S-EPMC10576715 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature