Copper metabolism-related Genes in entorhinal cortex for Alzheimer's disease.

ABSTRACT: The pathological features of Alzheimer's disease are the formation of amyloid plaques and entanglement of nerve fibers. Studies have shown that Cu may be involved in the formation of amyloid plaques. However, their role has been controversial. The aim of this study was to explore the role of Cu in AD. We applied the "R" software for our differential analysis. Differentially expressed genes were screened using the limma package. Copper metabolism-related genes and the intersection set of differential genes with GSE5281 were searched; functional annotation was performed. The protein-protein interaction network was constructed using several modules to analyse the most significant hub genes. The hub genes were then qualified, and a database was used to screen for small-molecule AD drugs. We id

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10576783 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature