KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.

ABSTRACT: The hippocampus plays major roles in learning and memory, and its formation requires precise coordination of patterning, cell proliferation, differentiation, and migration. Here we removed the chromatin-association capability of KDM2B in the progenitors of developing dorsal telencephalon (Kdm2b^∆CxxC) to discover that Kdm2b^∆CxxC hippocampus, particularly the dentate gyrus, became drastically smaller with disorganized cellular components and structure. Kdm2b^∆CxxC mice display prominent defects in spatial memory, motor learning and fear conditioning, resembling patients with KDM2B mutations. The migration and differentiation of neural progenitor cells is greatly impeded in the developing Kdm2b^∆CxxC hippocampus. Mechanism studies reveal that Wnt sign

SUBMITTER: Zhang B 

PROVIDER: S-EPMC10576813 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature