Abl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species.

ABSTRACT: Alzheimer's disease is the most common age-associated neurodegenerative disorder and the most frequent form of dementia in our society. Aging is a complex biological process concurrently shaped by genetic, dietary and environmental factors and natural compounds are emerging for their beneficial effects against age-related disorders. Besides their antioxidant activity often described in simple model organisms, the molecular mechanisms underlying the beneficial effects of different dietary compounds remain however largely unknown. In the present study, we exploit the nematode Caenorhabditis elegans as a widely established model for aging studies, to test the effects of different natural compounds in vivo and focused on mechanistic aspects of one of them, quercetin, using complementary system

SUBMITTER: Schiavi A 

PROVIDER: S-EPMC10576830 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature