Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila.

ABSTRACT: A neuron's regenerative capacity is governed by its intrinsic and extrinsic environment. Both peripheral and central neurons exhibit cell-type-dependent axon regeneration, but the underlying mechanism is unclear. Glia provide a milieu essential for regeneration. However, the routes of glia-neuron signaling remain underexplored. Here, we show that regeneration specificity is determined by the axotomy-induced Ca²⁺ transients only in the fly regenerative neurons, which is mediated by L-type calcium channels, constituting the core intrinsic machinery. Peripheral glia regulate axon regeneration via a three-layered and balanced modulation. Glia-derived tumor necrosis factor acts through its neuronal receptor to maintain calcium channel expression after injury. Glia sustain calcium cha

SUBMITTER: Trombley S 

PROVIDER: S-EPMC10576831 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature