Demographic modeling of admixed Latin American populations from whole genomes.

ABSTRACT: Demographic models of Latin American populations often fail to fully capture their complex evolutionary history, which has been shaped by both recent admixture and deeper-in-time demographic events. To address this gap, we used high-coverage whole-genome data from Indigenous American ancestries in present-day Mexico and existing genomes from across Latin America to infer multiple demographic models that capture the impact of different timescales on genetic diversity. Our approach, which combines analyses of allele frequencies and ancestry tract length distributions, represents a significant improvement over current models in predicting patterns of genetic variation in admixed Latin American populations. We jointly modeled the contribution of European, African, East Asian, and Indigenous Am

SUBMITTER: Medina-Munoz SG 

PROVIDER: S-EPMC10577084 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature