Multivariate piecewise linear regression model to predict radiosensitivity using the association with the genome-wide copy number variation.

ABSTRACT:

Introduction

The search for biomarkers to predict radiosensitivity is important not only to individualize radiotherapy of cancer patients but also to forecast radiation exposure risks. The aim of this study was to devise a machine-learning method to stratify radiosensitivity and to investigate its association with genome-wide copy number variations (CNVs) as markers of sensitivity to ionizing radiation.

Methods

We used the Affymetrix CytoScan HD microarrays to survey common CNVs in 129 fibroblast cell strains. Radiosensitivity was measured by the surviving fraction at 2 Gy (SF2). We applied a dynamic programming (DP) algorithm to create a piecewise (segmented) multivariate linear regression model predicting SF2 and to identify SF2 segment-related distinctive CNVs.

Results

SUBMITTER: Tobiasz J 

PROVIDER: S-EPMC10577171 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature