Infections associated with clozapine: a pharmacovigilance study using VigiBase^®.

ABSTRACT: Introduction: Clozapine is primarily reserved for treatment-resistant schizophrenia due to safety concerns associated with its use. Infections have been reported with clozapine, which may lead to elevated serum levels of the drug. However, the existing literature on this topic is limited. Therefore, we conducted a study using VigiBase^® to investigate the potential over-reporting of infections associated with clozapine, to explore the presence of dose-dependency, and to investigate the underlying mechanism. Methods: Disproportionality analyses were performed using VigiBase to assess the association between clozapine and all types of infections, the association between clozapine-associated infections and neutropenia, the association between clozapine-associated infec

SUBMITTER: Chretien B 

PROVIDER: S-EPMC10577313 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature