Systemic inflammation early after kidney transplantation is associated with long-term graft loss: a cohort study.

ABSTRACT:

Background

Early graft loss following kidney transplantation is mainly a result of acute rejection or surgical complications, while long-term kidney allograft loss is more complex. We examined the association between systemic inflammation early after kidney transplantation and long-term graft loss, as well as correlations between systemic inflammation scores and inflammatory findings in biopsies 6 weeks and 1 year after kidney transplantation.

Methods

We measured 21 inflammatory biomarkers 10 weeks after transplantation in 699 patients who were transplanted between 2009 and 2012 at Oslo University Hospital, Rikshospitalet, Norway. Low-grade inflammation was assessed with predefined inflammation scores based on specific biomarkers: one overall inflammation score and five path

SUBMITTER: Heldal TF 

PROVIDER: S-EPMC10577420 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature