The stratification and prognostic importance of molecular and immune landscapes in clear cell renal cell carcinoma.

ABSTRACT: The aim of our research is to explore the various characteristics and genetic profiles of clear cell renal cell carcinoma (ccRCC) in order to discover possible predictors of prognosis and targets for treatment. By utilizing ssGSEA scores, we categorized patients with ccRCC into groups based on their phenotype, distinguishing between low and high. This categorization revealed significant variations in the expression of crucial immune checkpoint genes and Human Leukocyte Antigen (HLA) genes, suggesting the presence of a potential immune evasion tactic in different subtypes of ccRCC. A predictive model was built using genes that are expressed differently and linked to cell death, showing strong effectiveness in categorizing patient risk. Furthermore, we discovered a noteworthy correlation amo

SUBMITTER: Zhai X 

PROVIDER: S-EPMC10577421 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature