Proteomic changes to immune and inflammatory processes underlie lung preservation using ex vivo cytokine adsorption.

ABSTRACT:

Introduction

In recent years, the field of graft preservation has made considerable strides in improving outcomes related to solid organ restoration and regeneration. Ex vivo lung perfusion (EVLP) in line with the related devices and treatments has yielded promising results within preclinical and clinical studies, with the potential to improve graft quality. Its main benefit is to render marginal and declined donor lungs suitable for transplantation, ultimately increasing the donor pool available for transplantation. In addition, using such therapies in machine perfusion could also increase preservation time, facilitating logistical planning. Cytokine adsorption has been demonstrated as a potentially safe and effective therapy when applied to the EVLP circuit and post-transplantati

SUBMITTER: Niroomand A 

PROVIDER: S-EPMC10577429 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature