Residual Kidney Function and Cause-Specific Mortality Among Incident Hemodialysis Patients.

ABSTRACT:

Introduction

The survival benefit of residual kidney function (RKF) in patients on hemodialysis is presumably due to enhanced fluid management and solute clearance. However, data are lacking on the association of renal urea clearance (CL_urea) with specific causes of death.

Methods

We conducted a longitudinal cohort study of 39,623 adults initiating thrice-weekly in-center hemodialysis from 2007 to 2011 and had data on renal CL_urea and urine volume. Multivariable cause-specific proportional hazards model was used to examine the associations between baseline RKF and cause-specific mortality, including sudden cardiac death (SCD), non-SCD cardiovascular death (CVD), and non-CVD. Restricted cubic splines were fitted for change in RKF over 6 months after init

SUBMITTER: Okazaki M 

PROVIDER: S-EPMC10577493 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature