Efficacy of sacubitril-valsartan and SGLT2 inhibitors in heart failure with reduced ejection fraction: A systematic review and meta-analysis.

ABSTRACT:

Background

Sacubitril-valsartan (SV) monotherapy has been shown to help patients with Heart failure with reduced ejection fraction (HFrEF), but whether adding a sodium-glucose cotransporter-2 inhibitor (SGLT2i) improves treatment results even more is unknown.

Hypothesis

The goal of this study was to look at the efficacy of SV with additional SGLT2i in HFrEF patients.

Methods

For this study, several databases, such as PubMed, EMBASE, Web of Science, and the Cochrane Library, were searched. A coherent search approach was used for data extraction. Review Manager 5.2 and MedCalc were used for conducting the meta-analysis and bias analysis. A meta-regression study correlates patient mean age with primary and secondary outcomes.

Results

Seven trials totaling 16 100 p

SUBMITTER: Mo X 

PROVIDER: S-EPMC10577570 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature