Infrared and Raman Diagnostic Modeling of Phosphate Adsorption on Ceria Nanoparticles.

ABSTRACT: Cerium dioxide (CeO₂; ceria) nanoparticles (CeNPs) are promising nanozymes that show a variety of biological activity. Effective nanozymes need to retain their activity in the face of surface speciation in biological environments, and characterizing surface speciation is therefore critical to understanding and controlling the therapeutic capabilities of CeNPs. In particular, adsorbed phosphates can impact the enzymatic activity exploited to convert phosphate prodrugs into therapeutics in vivo and also define the early stages of the phosphate-scavenging processes that lead to the transformation of active CeO₂ into inactive CePO₄. In this work, we utilize ab initio lattice-dynamics calculations to study the interaction of phosphates with the thr

SUBMITTER: Ta KM 

PROVIDER: S-EPMC10577678 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature