Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood.

ABSTRACT:

Background

Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may also have intergenerational health effects by which parental ACEs are associated with mental and physical health of children. Epigenetic programming may be one mechanism linking parental ACEs to child health. This study aimed to investigate epigenome-wide associations of maternal preconception ACEs with DNA methylation patterns of children. In the Center for the Health Assessment of Mothers and Children of Salinas study, cord blood DNA methylation was measured using the Illumina HumanMethylation450 BeadChip. Preconception ACEs, which occurred during the mothers' childhoods, were collected using a standard ACE questionnaire including 10 ACE indicators.

SUBMITTER: Collender P 

PROVIDER: S-EPMC10577922 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature