Microbial signatures in amniotic fluid at preterm birth and association with bronchopulmonary dysplasia.

ABSTRACT:

Background

Microbiome dysbiosis can have long-lasting effects on our health and induce the development of various diseases. Bronchopulmonary dysplasia (BPD) is a multifactorial disease with pre- and postnatal origins including intra-amniotic infection as main risk factor. Recently, postnatal pathologic lung microbiota colonization was associated with BPD. The objectives of this prospective observational cohort study were to describe differences in bacterial signatures in the amniotic fluid (AF) of intact pregnancies without clinical signs or risk of preterm delivery and AF samples obtained during preterm deliveries and their variations between different BPD disease severity stages.

Methods

AF samples were collected under sterile conditions during fetal intervention from inta

SUBMITTER: Staude B 

PROVIDER: S-EPMC10577941 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature