Immunomodulation by cannabidiol in bovine primary ruminal epithelial cells.

ABSTRACT:

Background

Ruminant livestock experience a number of challenges, including high concentrate diets, weaning and transport, which can increase their risk of disorders such as ruminal acidosis, and the associated inflammation of the ruminal epithelium. Cannabidiol (CBD), a phytochemical from hemp (Cannabis sativa), is a promising target as a therapy for gastrointestinal inflammation, and may be extremely valuable as either a treatment or prophylactic. However, the effects of CBD in the the ruminant gastrointestinal tract have not been explored, in part due to the restrictions on feeding hemp to livestock. Therefore, the objective of this study was to investigate the immunomodulatory properties of CBD using a model of inflammation in primary ruminal epithelial cells (REC). In addition,

SUBMITTER: Kent-Dennis C 

PROVIDER: S-EPMC10577946 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature