The Molecular Tumor Board of the Regina Elena National Cancer Institute: from accrual to treatment in real-world.

ABSTRACT:

Background

Molecular Tumor Boards (MTB) operating in real-world have generated limited consensus on good practices for accrual, actionable alteration mapping, and outcome metrics. These topics are addressed herein in 124 MTB patients, all real-world accrued at progression, and lacking approved therapy options.

Methods

Actionable genomic alterations identified by tumor DNA (tDNA) and circulating tumor DNA (ctDNA) profiling were mapped by customized OncoKB criteria to reflect diagnostic/therapeutic indications as approved in Europe. Alterations were considered non-SoC when mapped at either OncoKB level 3, regardless of tDNA/ctDNA origin, or at OncoKB levels 1/2, provided they were undetectable in matched tDNA, and had not been exploited in previous therapy lines.

Results

SUBMITTER: Giacomini P 

PROVIDER: S-EPMC10577953 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature