Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges.

ABSTRACT: RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the COVID-19 pandemic. Since their development in the 1990s, RNA interference (RNAi) therapeutics have demonstrated potential in reducing the expression of disease-associated genes. Nucleic acid-based therapeutics, including RNAi therapies, that degrade viral genomes and rapidly adapt to viral mutations, have emerged as alternative treatments. RNAi is a robust technique frequently employed to selectively suppress gene expression in a sequence-specific manner. The swift adaptability of nucleic acid-based therapeutics such as RNAi therapies endows them with a significant advantage over other

SUBMITTER: Kang H 

PROVIDER: S-EPMC10577957 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature