Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.

ABSTRACT:

Background

With the development and popularization of low-dose chest CT technology, the diagnosis and survival rates of patients with early lung cancer (LC) have significantly improved. The occurrence of colorectal cancer (CRC) as the second primary cancer (SPC) in primary lung cancer (PLC) survivors has become an essential factor affecting the prognosis of early LC. This study explored the potential association between PLC and CRC genetically, laying a foundation for developing SPC-CRC prevention strategies after primary early LC.

Methods

Based on a two-sample bidirectional Mendelian randomization (MR) design, this study systematically screened genetic instrumental variables (IVs) based on the genome-wide association studies (GWAS) of PLC and CRC, applied inverse variance w

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC10577972 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature