Metabolomics in severe traumatic brain injury: a scoping review.

ABSTRACT:

Background

Diagnosis and prognostication of severe traumatic brain injury (sTBI) continue to be problematic despite years of research efforts. There are currently no clinically reliable biomarkers, though advances in protein biomarkers are being made. Utilizing Omics technology, particularly metabolomics, may provide new diagnostic biomarkers for sTBI. Several published studies have attempted to determine the specific metabolites and metabolic pathways involved; these studies will be reviewed.

Aims

This scoping review aims to summarize the current literature concerning metabolomics in sTBI, review the comprehensive data, and identify commonalities, if any, to define metabolites with potential clinical use. In addition, we will examine related metabolic pathways through pathw

SUBMITTER: Fedoruk RP 

PROVIDER: S-EPMC10577974 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature