Relationship between gut microbiota dysbiosis and immune indicator in children with sepsis.

ABSTRACT: Sepsis is a life-threatening multiple-organ injury caused by disordered host immune response to microbial infection. However, the correlation between gut microbiota dysbiosis and immune indicators remains unexplored. To address this gap in knowledge, we carried out 16 S rDNA sequencing, analyzed clinical fecal samples from children with sepsis (n = 30) and control children (n = 25), and obtained immune indicators, including T cell subtypes (CD3⁺, CD3⁺CD4⁺, CD3⁺CD8⁺, and CD4/CD8), NK cells, cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ), and immunoglobulin indices (IgA, IgE, IgM and IgG). In addition, we analyzed the correlation between gut microbiota dysbiosis and immune indicators, and evaluated the clinical discriminatory power

SUBMITTER: Lin X 

PROVIDER: S-EPMC10578006 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature