Memantine administration prevented chorea movement in Huntington's disease: a case report.

ABSTRACT:

Background

Huntington's disease is an autosomal dominant inherited disorder characterized by personality changes (such as irritability and restlessness) and psychotic symptoms (such as hallucinations and delusions). When the personality changes become noticeable, involuntary movements (chorea) also develop. The disease is caused by the CAG repeat expansion in the coding region of the HTT gene, and the diagnosis is based on the presence of this expansion. However, there is currently no effective treatment for the progression of Huntington's disease and its involuntary motor symptoms. Herein, we present a case in which memantine was effective in treating the chorea movements of Huntington's disease.

Case presentation

A 75-year-old Japanese woman presented to the hospital with

SUBMITTER: Saigoh K 

PROVIDER: S-EPMC10578007 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature