Identification of potential CD8+ epitopes in pp62 polyprotein of African swine fever virus using computational immunology.

ABSTRACT: The highly infectious African swine fever virus (ASFV) is currently the only known DNA arbovirus within the Asfarviridae family which primarily infects domestic pigs and wild boars. African swine fever (ASF) leads to a mortality rate of up to 100% which has caused massive socio-economic losses worldwide. Previous research indicates that ASFV's virulence can be attributed to polyprotein pp62, which plays a crucial role in viral assembly and core maturation. This particular study utilized in silico analysis to identify highly conserved cytotoxic T-cell epitopes in pp62 that can potentially serve as key components for future ASFV vaccines. To achieve this, the researchers retrieved, clustered, and aligned the peptide sequences of pp62. Subsequently, the aligned sequences were an

SUBMITTER: Galicia MLC 

PROVIDER: S-EPMC10578124 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature