Parkinson's Progression Markers Initiative: A Milestone-Based Strategy to Monitor Parkinson's Disease Progression.

ABSTRACT:

Background

Identifying a meaningful progression metric for Parkinson's disease (PD) that reflects heterogeneity remains a challenge.

Objective

To assess the frequency and baseline predictors of progression to clinically relevant motor and non-motor PD milestones.

Methods

Using data from the Parkinson's Progression Markers Initiative (PPMI) de novo PD cohort, we monitored 25 milestones across six domains ("walking and balance"; "motor complications"; "cognition"; "autonomic dysfunction"; "functional dependence"; "activities of daily living"). Milestones were intended to be severe enough to reflect meaningful disability. We assessed the proportion of participants reaching any milestone; evaluated which occurred most frequently; and conducted a time-to-first-event analys

SUBMITTER: Brumm MC 

PROVIDER: S-EPMC10578214 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature