The Mediating Roles of Neurobiomarkers in the Relationship Between Education and Late-Life Cognition.

ABSTRACT:

Background

The mediating roles of neuropathologies and neurovascular damage in the relationship between early-life education and later-life cognitive function are unknown.

Objective

To examine whether Alzheimer's and neurovascular biomarkers mediate the relationships between education and cognitive functions.

Methods

Data were from 537 adults aged 55-94 in the Alzheimer's Disease Neuroimaging Initiative 3. We tested whether the relationships between education (continuous, years) and cognitive function (memory, executive functioning, and language composites) were mediated by neuroimaging biomarkers (hippocampal volumes, cortical gray matter volumes, meta-temporal tau PET standard uptake value ratio, and white matter hyperintensity volumes). Models were adjusted for age

SUBMITTER: Amofa-Ho PA 

PROVIDER: S-EPMC10578223 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature