Delayed and More Variable Unimanual and Bimanual Finger Tapping in Alzheimer's Disease: Associations with Biomarkers and Applications for Classification.

ABSTRACT:

Background

Despite reports of gross motor problems in mild cognitive impairment (MCI) and Alzheimer's disease (AD), fine motor function has been relatively understudied.

Objective

We examined if finger tapping is affected in AD, related to AD biomarkers, and able to classify MCI or AD.

Methods

Forty-seven cognitively normal, 27 amnestic MCI, and 26 AD subjects completed unimanual and bimanual computerized tapping tests. We tested 1) group differences in tapping with permutation models; 2) associations between tapping and biomarkers (PET amyloid-β, hippocampal volume, and APOEɛ4 alleles) with linear regression; and 3) the predictive value of tapping for group classification using machine learning.

Results

AD subjects had slower reaction time and larger speed var

SUBMITTER: Koppelmans V 

PROVIDER: S-EPMC10578230 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature