Incidence of Alzheimer's Disease in Men with Late-Life Hypertension Is Ameliorated by FOXO3 Longevity Genotype.

ABSTRACT:

Background

It is well established that mid-life hypertension increases risk of dementia, whereas the association of late-life hypertension with dementia is unclear.

Objective

To determine whether FOXO3 longevity-associated genotype influences the association between late-life hypertension and incident dementia.

Methods

Subjects were 2,688 American men of Japanese ancestry (baseline age: 77.0±4.1 years, range 71-93 years) from the Kuakini Honolulu Heart Program. Status was known for FOXO3 rs2802292 genotype, hypertension, and diagnosis of incident dementia to 2012. Association of FOXO3 genotype with late-life hypertension and incident dementia, vascular dementia (VaD) and Alzheimer's disease (AD) was assessed using Cox proportional hazards models.

Results

During

SUBMITTER: Chen R 

PROVIDER: S-EPMC10578238 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature