Inspiratory Muscle Training in Nemaline Myopathy.

ABSTRACT:

Background

Respiratory muscle weakness is a common feature in nemaline myopathy. Inspiratory muscle training (IMT) is an intervention that aims to improve inspiratory muscle strength.

Objective

The aim of this controlled before-and-after pilot study was to investigate if IMT improves respiratory muscle strength in patients with nemaline myopathy.

Methods

Nine patients (7 females; 2 males, age 36.6±20.5 years) with respiratory muscle weakness and different clinical phenotypes and genotypes were included. Patients performed eight weeks of sham IMT followed by eight weeks of active threshold IMT. The patients trained twice a day five days a week for 15 minutes at home. The intensity was constant during the training after a gradual increase to 30% of maximal inspiratory p

SUBMITTER: van Kleef ESB 

PROVIDER: S-EPMC10578271 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature