Exploring the Complex Phenotypes of Impaired Finger Dexterity in Mild-to-moderate Stage Parkinson's Disease: A Time-Series Analysis.

ABSTRACT:

Background

Impaired dexterity is an early motor symptom in Parkinson's disease (PD) that significantly impacts the daily activity of patients; however, what constitutes complex dexterous movements remains controversial.

Objective

To explore the characteristics of finger dexterity in mild-to-moderate stage PD.

Methods

We quantitatively assessed finger dexterity in 48 mild-to-moderate stage PD patients and 49 age-matched controls using a simple alternating two-finger typing test for 15 seconds. Time-series analyses of various kinematic parameters with machine learning were compared between sides and groups.

Results

Both the more and less affected hands of patients with PD had significantly lower typing frequency and slower typing velocity than the non-dominant an

SUBMITTER: Panyakaew P 

PROVIDER: S-EPMC10578277 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature