Direct Conversion of Fibroblast into Neurons for Alzheimer's Disease Research: A Systematic Review.

ABSTRACT:

Background

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder without a cure. Innovative disease models, such as induced neurons (iNs), could enhance our understanding of AD mechanisms and accelerate treatment development. However, a review of AD human iN studies is necessary to consolidate knowledge.

Objective

The objective of this review is to examine the current body of literature on AD human iN cells and provide an overview of the findings to date.

Methods

We searched two databases for relevant studies published between 2010 and 2023, identifying nine studies meeting our criteria.

Results

Reviewed studies indicate the feasibility of generating iNs directly from AD patients' fibroblasts using chemical induction or viral vectors. These cells e

SUBMITTER: Sattarov R 

PROVIDER: S-EPMC10578293 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature