Reversible Pulsed Electrical Fields as an In Vivo Tool to Study Cardiac Electrophysiology: The Advent of Pulsed Field Mapping.

ABSTRACT:

Background

During electrophysiological mapping of tachycardias, putative target sites are often only truly confirmed to be vital after observing the effect of ablation. This lack of mapping specificity potentiates inadvertent ablation of innocent cardiac tissue not relevant to the arrhythmia. But if myocardial excitability could be transiently suppressed at critical regions, their suitability as targets could be conclusively determined before delivering tissue-destructive ablation lesions. We studied whether reversible pulsed electric fields (PF_REV) could transiently suppress electrical conduction, thereby providing a means to dissect tachycardia circuits in vivo.

Methods

PF_REV energy was delivered from a 9-mm lattice-tip catheter to the atria of 12 swi

SUBMITTER: Koruth JS 

PROVIDER: S-EPMC10578517 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature