Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease.

ABSTRACT:

Background

Chronic alcohol consumption impairs gut barrier function and perturbs the gut microbiome. Although shifts in bacterial communities in patients with alcohol-associated liver disease (ALD) have been characterized, less is known about the interactions between host metabolism and circulating microbe-derived metabolites during the progression of ALD.

Methods

A large panel of gut microbiome-derived metabolites of aromatic amino acids was quantified by stable isotope dilution liquid chromatography with online tandem mass spectrometry in plasma from healthy controls (n = 29), heavy drinkers (n = 10), patients with moderate (n = 16) or severe alcohol-associated hepatitis (n = 40), and alcohol-associated cirrhosis (n = 10).

Results

The tryptophan metabolites, seroton

SUBMITTER: Mrdjen M 

PROVIDER: S-EPMC10578770 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature