Vitamin D receptor and binding protein genes variants in patients with migraine.

ABSTRACT:

Background/objectives

Several studies have shown a relationship between vitamin D and migraine, including the association between decreased serum 25-hydroxyvitamin D in patients with migraine and the positive effects of vitamin D supplementations in the therapy of this disease. Two single-nucleotide variants (SNVs) vitamin D receptor (VDR) gene, VDR rs2228570, and VDR rs731236 have shown an association with migraine risk in a previous case-control association study, while an exome sequencing study identified a rare variant in GC vitamin D binding protein gene. This study aims to look for the association between several common variants in these two genes and the risk for migraine.

Methods

We genotyped 290 patients diagnosed with migraine and 300 age-matched controls using spe

SUBMITTER: Garcia-Martin E 

PROVIDER: S-EPMC10578880 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature