Pupillary dynamics predict long-term outcome in a cohort of acute traumatic brain injury coma patients.

ABSTRACT:

Objective

Examining the size and reactivity of the pupils of traumatic brain injury coma patients is fundamental in the Neuro-intensive care unit (ICU). Pupil parameters on admission predict long-term clinical outcomes. However, little is known about the dynamics of pupillary parameters and their potential value for outcome prediction.

Methods

This study applied a time-course analysis of pupillary signals (size and photo-reactivity) in acute traumatic brain injury coma patients (n = 20) to predict outcome at 6 months.

Results

The time course of pupillary signals was informative in discriminating favorable (F) versus unfavorable (U) outcomes, with the highest correlation within the 1st week notwithstanding pharmacological sedation. Patients with favorable outcome at 6 

SUBMITTER: Monai E 

PROVIDER: S-EPMC10578890 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature