Epigenetic regulation of vascular smooth muscle cell phenotypic switch and neointimal formation by PRMT5.

ABSTRACT:

Aims

Phenotypic transition of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic state is involved in the development of cardiovascular diseases, including atherosclerosis, hypertension, and post-angioplasty restenosis. Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) has been implicated in multiple cellular processes, however, its role in VSMC biology remains undetermined. The objective of this study was to determine the role of PRMTs in VSMC phenotypic switch and vascular remodelling after injury.

Methods and results

Our results show that PRMT5 is the most abundantly expressed PRMT in human aortic SMCs, and its expression is up-regulated in platelet-derived growth factor (PDGF)-stimulated VSMCs, human atherosclerotic lesions

SUBMITTER: Zhu N 

PROVIDER: S-EPMC10578915 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature