Impact of impaired pulmonary function on clinical outcomes in survivors of severe COVID-19 without pre-existing respiratory disease.

ABSTRACT:

Objective

To investigate the impact of impaired pulmonary function on patient-centered outcomes after hospital discharge due to severe COVID-19 in patients without preexisting respiratory disease.

Methods

This is an ongoing prospective cohort study evaluating patients (> 18 years of age) 2-6 months after hospital discharge due to severe COVID-19. Respiratory symptoms, health-related quality of life, lung function, and the six-minute walk test were assessed. A restrictive ventilatory defect was defined as TLC below the lower limit of normal, as assessed by plethysmography. Chest CT scans performed during hospitalization were scored for the presence and extent of parenchymal abnormalities.

Results

At a mean follow-up of 17.2 ± 5.9 weeks after the diagnosis of COVID-19,

SUBMITTER: Benedetto IG 

PROVIDER: S-EPMC10578918 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature