Natriuresis-guided diuretic therapy in acute heart failure: a pragmatic randomized trial.

ABSTRACT: Measurement of natriuresis has been suggested as a reliable, easily obtainable biomarker for assessment of the response to diuretic treatment in patients with acute heart failure (AHF). Here, to assess whether natriuresis-guided diuretic therapy in patients with AHF improves natriuresis and clinical outcomes, we conducted the pragmatic, open-label Pragmatic Urinary Sodium-based algoritHm in Acute Heart Failure trial, in which 310 patients (45% female) with AHF requiring treatment with intravenous loop diuretics were randomly assigned to natriuresis-guided therapy or standard of care (SOC). In the natriuresis-guided arm, natriuresis was determined at set timepoints, prompting treatment intensification if spot urinary sodium levels were <70 mmol l^-1. The dual primary endpoints wer

SUBMITTER: Ter Maaten JM 

PROVIDER: S-EPMC10579092 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature