Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization.

ABSTRACT: Post-COVID cognitive deficits, including 'brain fog', are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the ability to work, yet their biological underpinnings remain unknown. In this prospective cohort study of 1,837 adults hospitalized with COVID-19, we identified two distinct biomarker profiles measured during the acute admission, which predict cognitive outcomes 6 and 12 months after COVID-19. A first profile links elevated fibrinogen relative to C-reactive protein with both objective and subjective cognitive deficits. A second profile links elevated D-dimer relative to C-reactive protein with subjective cognitive deficits and occupational impact. This second profile was mediated by fatigue and shortness of breath. N

SUBMITTER: Taquet M 

PROVIDER: S-EPMC10579097 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature