A genome-wide genomic score added to standard recommended stratification tools does not improve the identification of patients with very low bone mineral density.

ABSTRACT: The role of integrating genomic scores (GSs) needs to be assessed. Adding a GS to recommended stratification tools does not improve the prediction of very low bone mineral density. However, we noticed that the GS performed equally or above individual risk factors in discrimination.

Purpose

We aimed to investigate whether adding a genomic score (GS) to recommended stratification tools improves the discrimination of participants with very low bone mineral density (BMD).

Methods

BMD was measured in three thoracic vertebrae using CT. All participants provided information on standard osteoporosis risk factors. GSs and FRAX scores were calculated. Participants were grouped according to mean BMD into very low (<80 mg/cm³), low (80-120 mg/cm³), and normal (>120

SUBMITTER: Therkildsen J 

PROVIDER: S-EPMC10579117 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature