The "Mystery Cell Population" Residing in Murine Bone Marrow - A Missing Link Between Very Small Embryonic Like Stem Cells and Hematopoietic Stem Cells?

ABSTRACT: Bone marrow (BM) contains not only hematopoietic stem cells (HSCs) but also some very rare, early development, small quiescent stem cells that, upon activation, may differentiate across germlines. These small cells, named very small embryonic like stem cells (VSELs), can undergo specification into several types of cells including HSCs. Interestingly, murine BM is also home to a "mystery" population of small CD45⁺ stem cells with many of the phenotypic characteristics attributed to resting HSCs. Since the size of the "mystery" population cells are between that of VSELs and HSCs, and because CD45^- VSELs can be specified into CD45⁺ HSCs, we hypothesized that the quiescent CD45⁺ "mystery" population could be a missing developmental link between VSELs

SUBMITTER: Bujko K 

PROVIDER: S-EPMC10579127 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature