Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice.

ABSTRACT: Use of the synthetic opioid fentanyl increased ~300% in the last decade, including among women of reproductive ages. Adverse neonatal outcomes and long-term behavioral disruptions are associated with perinatal opioid exposure. Our previous work demonstrated that perinatal fentanyl exposed mice displayed enhanced negative affect and somatosensory circuit and behavioral disruptions during adolescence. However, little is known about molecular adaptations across brain regions that underlie these outcomes. We performed RNA sequencing across three reward and two sensory brain areas to study transcriptional programs in perinatal fentanyl exposed juvenile mice. Pregnant dams received 10 μg/ml fentanyl in the drinking water from embryonic day 0 (E0) through gestational periods until weaning at post

SUBMITTER: Olusakin J 

PROVIDER: S-EPMC10579237 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature