The clock gene Per1 may exert diurnal control over hippocampal memory consolidation.

ABSTRACT: The circadian system influences many different biological processes, including memory performance. While the suprachiasmatic nucleus (SCN) functions as the brain's central pacemaker, downstream "satellite clocks" may also regulate local functions based on the time of day. Within the dorsal hippocampus (DH), for example, local molecular oscillations may contribute to time-of-day effects on memory. Here, we used the hippocampus-dependent Object Location Memory task to determine how memory is regulated across the day/night cycle in mice. First, we systematically determined which phase of memory (acquisition, consolidation, or retrieval) is modulated across the 24 h day. We found that mice show better long-term memory performance during the day than at night, an effect that was specifically at

SUBMITTER: Bellfy L 

PROVIDER: S-EPMC10579262 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature