Risk factors and cardio-metabolic outcomes associated with metabolic-associated fatty liver disease in childhood.

ABSTRACT:

Background

Non-Alcoholic Fatty Liver Disease (NAFLD) is defined as increased liver fat percentage, and is the most common chronic liver disease in children. Rather than NAFLD, Metabolic-Associated Fatty Liver Disease (MAFLD), defined as increased liver fat with presence of adverse cardio-metabolic measures, might have more clinical relevance in children. We assessed the prevalence, risk-factors and cardio-metabolic outcomes of MAFLD at school-age.

Methods

This cross-sectional analysis was embedded in an ongoing population-based prospective cohort study started in 2001, in the Netherlands. In 1910 children of 10 years, we measured liver fat fraction by magnetic resonance imaging (MRI), body mass index (BMI), blood pressure, and lipids, insulin, and glucose concentrations. Chi

SUBMITTER: de Groot J 

PROVIDER: S-EPMC10579278 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature