Escherichia coli killing by epidemiologically successful sublineages of Shigella sonnei is mediated by colicins.

ABSTRACT:

Background

Shigella sp. are enteric pathogens which causes >125 million cases of shigellosis annually. S. sonnei accounts for about a quarter of those cases and is increasingly prevalent in industrialising nations. Being an enteric pathogen, S. sonnei benefits from outcompeting gut commensals such as Escherichia coli to establish itself and cause disease. There are numerous mechanisms that bacterial pathogens use to outcompete its rivals including molecules called colicins. A Type 6 Secretion System (T6SS) was recently described as contributing to E. coli killing in S. sonnei.

Methods

We used Bulk Phenotyping of Epidemiological Replicates (BPER) which combined bacterial Genome Wide Association Studies (bGWAS) and high throughput phenotyping on a collection of S. sonnei surve

SUBMITTER: De Silva PM 

PROVIDER: S-EPMC10579285 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature