Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity.

ABSTRACT: Impulsive choice has enduring trait-like characteristics and is defined by preference for small immediate rewards over larger delayed ones. Importantly, it is a determining factor in the development and persistence of substance use disorder (SUD). Emerging evidence from human and animal studies suggests frontal cortical regions exert influence over striatal reward processing areas during decision-making in impulsive choice or delay discounting (DD) tasks. The goal of this study was to examine how these circuits are involved in decision-making in animals with defined trait impulsivity. To this end, we trained adolescent male rats to stable behavior on a DD procedure and then re-trained them in adulthood to assess trait-like, conserved impulsive choice across development. We then used chemog

SUBMITTER: Wenzel JM 

PROVIDER: S-EPMC10579332 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature