Photoelectrochemical oxidative C(sp³)-H borylation of unactivated hydrocarbons.

ABSTRACT: Organoboron compounds are of high significance in organic synthesis due to the unique versatility of boryl substituents to access further modifications. The high demand for the incorporation of boryl moieties into molecular structures has witnessed significant progress, particularly in the C(sp³)-H borylation of hydrocarbons. Taking advantage of special characteristics of photo/electrochemistry, we herein describe the development of an oxidative C(sp³)-H borylation reaction under metal- and oxidant-free conditions, enabled by photoelectrochemical strategy. The reaction exhibits broad substrate scope (>57 examples), and includes the use of simple alkanes, halides, silanes, ketones, esters and nitriles as viable substrates. Notably, unconventional regioselectivity of C(

SUBMITTER: Zhong PF 

PROVIDER: S-EPMC10579347 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature