Systematic analysis reveals a pan-cancer SNHG family signature predicting prognosis and immunotherapy response.

ABSTRACT: Small nucleolar RNA host genes (SNHGs) are a special family of long non-coding RNAs (lncRNAs), which not only function in a way similar to other lncRNAs but also influence the intracellular level of small nucleolar RNAs to modulate cancers. However, the features of SNHGs and their role in the prognosis and immunotherapeutic response of human cancer have not been explored. We found that SNHGs were commonly deregulated and correlated with patient survival in various cancers. The critical role of DNA methylation and somatic alterations on deregulation was also identified. SNHG family score was significantly associated with survival, multiple tumor characteristics, and tumor microenvironment. SNHG-related risk score could serve as a prognostic and immunotherapeutic response biomarker based on

SUBMITTER: Zheng H 

PROVIDER: S-EPMC10579433 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature