Distinct defects in early innate and late adaptive immune responses typify impaired fracture healing in diet-induced obesity.

ABSTRACT: Bone fractures, the most common musculoskeletal injuries, heal through three main phases: inflammatory, repair, and remodeling. Around 10% of fracture patients suffer from impaired healing that requires surgical intervention, a huge burden on the healthcare system. The rate of impaired healing increases with metabolic diseases such as obesity-associated hyperglycemia/type 2 diabetes (T2D), an increasing concern given the growing incidence of obesity/T2D. Immune cells play pivotal roles in fracture healing, and obesity/T2D is associated with defective immune-cell functions. However, there is a gap in knowledge regarding the stoichiometry of immune cells that populate the callus and how that population changes during different phases of healing. Here, we used complementary global and single-

SUBMITTER: Khajuria DK 

PROVIDER: S-EPMC10579581 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature